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Medchemexpress LLC Nitrilotris(methylenephosphonic acid) | 6419-19-8 | 299.05 | 100 G
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Supplier:  Medchemexpress LLC HYW011425100G

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NTPO (Nitrilotris(methylenephosphonic acid)) is a potent DNA damage inducer that leads to genomic DNA damage and fragmentation, subsequently activating ATR-mediated cell cycle checkpoints. Its DNA damaging effects are effectively mitigated by the base excision repair (BER) pathway, but not by the nucleotide excision repair (NER) pathway, highlighting a specific mechanism of action within DNA repair processes.

  • Causes genomic DNA damage and fragmentation.
  • Activates ATR-mediated cell cycle checkpoints.
  • DNA damaging effects are abrogated by base excision repair (BER).
  • DNA damaging effects are not abrogated by nucleotide excision repair (NER).
  • Suitable for research applications.

Catalog No. 50-004-55138


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