Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC NK 252 1414963-82-8 5mg
Supplier: Apexbio Technology LLC C57155
NK 252 (CAS 1414963-82-8) is a small molecule known to activate the Nrf2 (nuclear factor-erythroid-2-related factor 2) pathway by directly binding the Keap1 domain responsible for Nrf2 interaction Through this mechanism NK 252 promotes the nuclear translocation and transcriptional activity of Nrf2 enhancing antioxidant response element (ARE)-driven gene expression In hepatic cell models NK 252 upregulated NQO1-ARE activity in a dose-dependent manner and conferred protection against H2O2-induced cytotoxicity In rat models of nonalcoholic steatohepatitis NK 252 reduced liver fibrosis decreased plasma ALT and AST increased hepatic NQO1 expression and suppressed fibrogenic gene expression NK 252 has also been shown to modulate drug resistance and augment the efficacy of antitumor agents in preclinical studies
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?