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Selleck Chemical LLC NLRP3/AIM2-IN-3 E5801-1G
Supplier: Selleck Chemical LLC E58011G
NLRP3/AIM2-IN-3 (compound 59) is a potent inhibitor with species-specific effects on NLRP3 and AIM2 inflammasome-mediated pyroptosis It demonstrates potent inhibition of pyroptosis in THP-1 macrophages stimulated with LPS/nigericin with an IC50 of 0 077 M It also disrupts the interaction between NLRP3 or AIM2 and the adaptor protein ASC effectively preventing ASC oligomerization and blocking inflammasome assembly
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