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Medchemexpress LLC (±)-Nornicotine | 5746-86-1 | 148.20 | 100 MG
Supplier: Medchemexpress LLC HYW002112100MG
(±)-Nornicotine is a major metabolite of Nicotine. It functions as a partial nAChRs agonist, specifically activating receptor subtypes containing α7 and α6 subunits. This compound disrupts β-catenin and ZO-1, and induces F-actin depolymerization. It supports self-administration behavior and is utilized in research for conditions such as atherosclerosis, Alzheimer's disease, and schizophrenia.
- Promotes cell migration in human endothelial cells
- Disrupts adherens junctions (β-catenin) and tight junctions (ZO-1)
- Induces F-actin depolymerization
- Maintains self-administration behavior in Sprague-Dawley rats
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