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Cayman Chemical NotogInsenosIde Ft1 10mg
Supplier: Cayman Chemical 2497610 MG
A saponin with diverse biological activities; induces proliferation, migration, and tube formation of HUVECs in an mTOR-dependent manner; induces cell cycle arrest at the S and G2/M phases and promotes apoptosis of SH-SY5Y cells at 45 μM; increases cGMP levels and induces relaxation of isolated precontracted rat mesenteric arteries; promotes angiogenesis and decreases wound diameter in a mouse model of punched-hole EAr injury at 0.25, 2.5, and 25 mg/kg; decreases tail bleeding time and increases thrombus weight in a rat tail bleeding assay at 1.25 mg/kg; increases mRNA expression of collagen expression, fibroblast proliferation, and scar formation genes; promotes neovascularization, reduces monocyte infiltration, and shortens wound closure time in a db/db mouse model of diabetic foot ulcers
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