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Apexbio Technology LLC NPS-2143 284035-33-2 200mg
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Supplier:  Apexbio Technology LLC B1424200

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NPS-2143 (CAS 284035-33-2) is a selective antagonist of the calcium-sensing receptor (CaSR) It attenuates the sensitivity of CaSR to extracellular calcium ([Ca2 ]o) thereby modulating downstream signaling and promoting parathyroid hormone (PTH) secretion in vivo In vitro studies demonstrate that NPS-2143 inhibits [Ca2 ]o-induced intracellular calcium signaling in HEK 293T cells expressing CaSR with an EC50 of 4 27 mM for the wild-type receptor It also reduces excessive signal transduction in cells expressing various activating CaSR mutations NPS-2143 is widely utilized in research investigating CaSR function calcium homeostasis and the pharmacological modulation of parathyroid hormone regulation

Catalog No. 50-000-89388


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