Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC NPS-2143 284035-33-2 200mg
Supplier: Apexbio Technology LLC B1424200
NPS-2143 (CAS 284035-33-2) is a selective antagonist of the calcium-sensing receptor (CaSR) It attenuates the sensitivity of CaSR to extracellular calcium ([Ca2 ]o) thereby modulating downstream signaling and promoting parathyroid hormone (PTH) secretion in vivo In vitro studies demonstrate that NPS-2143 inhibits [Ca2 ]o-induced intracellular calcium signaling in HEK 293T cells expressing CaSR with an EC50 of 4 27 mM for the wild-type receptor It also reduces excessive signal transduction in cells expressing various activating CaSR mutations NPS-2143 is widely utilized in research investigating CaSR function calcium homeostasis and the pharmacological modulation of parathyroid hormone regulation
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?