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Medchemexpress LLC NRX-2663 | 2763260-34-8 | 99.0% | C20H13F3N2O5 | 100 MG
Supplier: Medchemexpress LLC HY141448100MG
NRX-2663 is an enhancer of the interaction between β-catenin and its cognate E3 ligase, SCFβ-TrCP. It enhances the binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 μM and a Kd of 54.8 nM. It also significantly enhances the ubiquitylation of the pSer33/Ser37 β-catenin peptide, making it suitable for laboratory research.
- Enhances binding of β-catenin peptide for β-TrCP with an EC50 of 22.9 μM
- Shows improved potency in binding assay with pSer33/Ser37 β-catenin (EC50 of 80 μM)
- Provides 13-fold cooperativity of binding
- Significantly enhances ubiquitylation of the pSer33/Ser37 β-catenin peptide
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