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Medchemexpress LLC NS1643 | 448895-37-2 | 99.04% | 380.24 | 25 MG
Supplier: Medchemexpress LLC 25MGHY16916
NS1643 is a partial agonist of human ether-a-go-go-related gene (hERG) K+ channels with an EC50 of 10.5 μM. It inhibits the growth of breast cancer tumors in TNBC mouse models and also inhibits cell migration and invasion of breast cancer cells.
- Partial agonist of hERG K+ channels (EC50 of 10.5 μM)
- Inhibits breast cancer tumor growth in TNBC mouse models
- Inhibits cell migration and invasion of breast cancer cells
- Dose- and voltage-dependently increases hERG current in oocytes
- Slows the rate of hERG inactivation and reduces hERG channel rectification
- Decreases Vimentin, N-cadherin, and CD44 levels, and increases E-cadherin in breast cancer cell lines (MDA-MB-231, SKBR3, and MCF7)
- Inhibits breast tumor metastasis in NSG mice with human-derived TNBC tumor xenografts
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