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Apexbio Technology LLC NS3694 426834-38-0 5mg
Supplier: Apexbio Technology LLC C44685
NS3694 (CAS 426834-38-0) is a diarylurea small molecule that functions as an inhibitor of apoptosome formation and caspase activation In HeLa cell cytosolic extracts NS3694 demonstrates an IC50 of approximately 50 M for the inhibition of cytochrome c-induced caspase activity It blocks the association of caspase 9 and Apaf-1 thereby preventing assembly of the functional 700-kDa apoptosome complex without directly inhibiting recombinant caspase 9 or caspase 3 NS3694 does not affect TNF-induced or FasL-induced caspase activation in other contexts This compound serves as a research tool for investigating intrinsic apoptotic signaling and apoptosome-mediated caspase activation in vitro
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