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Medchemexpress LLC NSC-87877 disodium | 56932-43-5 | 98.0% | 503.42 | 5 MG
Supplier: Medchemexpress LLC HY18756A5MG
NSC-87877 disodium is a potent inhibitor of protein tyrosine phosphatases, specifically Shp2 and Shp1, exhibiting IC50 values of 0.318 μM and 0.355 μM respectively. Additionally, this compound demonstrates inhibitory activity against dual-specificity phosphatase 26 (DUSP26). It has shown promising anti-neuroblastoma activity in animal models by inhibiting tumor growth, and in vitro studies indicate it induces p53-mediated apoptosis in various neuroblastoma cell lines. The product is intended for research use only.
- Potent inhibition of Shp2 and Shp1 protein tyrosine phosphatases.
- Inhibits dual-specificity phosphatase 26 (DUSP26).
- Demonstrates anti-neuroblastoma activity.
- Induces p53 phosphorylation and activation.
- Results in apoptosis in various cell lines.
- Suppresses neuroblastoma tumor growth in animal models.
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