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Medchemexpress LLC NU9056 | 1450644-28-6 | 98.8% | 232.37 | 1 MG
SDP

Supplier:  Medchemexpress LLC HY11012710MG

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NU9056 is a potent and selective Tip60 (KAT5) histone acetyltransferase inhibitor with an IC50 of 2 μM. It demonstrates over 16-fold selectivity for Tip60 compared to PCAF, p300, and GCN5. This compound is known to induce apoptosis in prostate cancer cells.

  • Activates caspase 3 and caspase 9 in a time- and concentration-dependent manner.
  • Decreases acetylated histone H4K16, H3K14, and H4K8 levels.
  • Reduces androgen receptor, prostate-specific antigen, p53, and p21 protein levels.
  • Induces apoptosis in LNCaP cells.

Catalog No. 50-003-44025


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