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Medchemexpress LLC NUCC-390 | 1060524-97-1 | 98.40% | 395.54 | 10 MG
SDP

Supplier:  Medchemexpress LLC HY11179310MG

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NUCC-390 is a novel and selective small-molecule CXCR4 receptor agonist. It induces internalization of CXCR4 receptors and promotes nerve recovery of function after neurodegeneration in vivo.

  • Novel and selective small-molecule CXCR4 receptor agonist.
  • Induces internalization of CXCR4 receptors.
  • Acts in an opposite way of AMD3100.
  • Promotes nerve recovery of function after neurodegeneration in vivo.
  • Produces strong (Ca)i response, which can be blocked by AMD3100.
  • Increases levels of pERK, stimulating signaling activity downstream of CXCR4 receptors.
  • Induces CXCR4 receptor internalization in HEK cells.
  • Boosts axonal growth in cultured cerebellar granule neurons (CGNs) via CXCR4.
  • Contributes to the functional and anatomical recovery of the neuromuscular junction (NMJ) following acute nerve terminal damage in CD-1 mice.

Catalog No. 50-004-39185


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