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Apexbio Technology LLC (±)-Nutlin-3 548472-68-0 10mg
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Supplier:  Apexbio Technology LLC B605810

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( )-Nutlin-3 (CAS 548472-68-0) is a small molecule antagonist of MDM2 a regulator that negatively modulates the tumor suppressor protein p53 By inhibiting the interaction between p53 and MDM2 (IC50 0 09 M) ( )-Nutlin-3 promotes p53 stabilization and activation leading to enhanced transcription of p53 target genes such as CDKN1A/p21 and GADD45 In cellular studies ( )-Nutlin-3 induces dose-dependent p53 accumulation and apoptosis including in B-cell chronic lymphocytic leukemia cells In murine xenograft models oral administration suppresses tumor growth and increases caspase-3 activity ( )-Nutlin-3 is widely used to investigate p53-dependent cell death and tumor biology in preclinical research

Catalog No. 50-000-92758


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