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Apexbio Technology LLC NVP-AEW541 475489-16-8 25mg
Supplier: Apexbio Technology LLC A227825
NVP-AEW541 (CAS 475489-16-8) is a selective small-molecule inhibitor targeting the insulin-like growth factor-I receptor (IGF-IR) kinase activity Structurally classified as a pyrrolo[2 3-d]pyrimidine derivative NVP-AEW541 effectively inhibits IGF-IR autophosphorylation disrupting downstream IGF-IR mediated signaling cascades It exhibits an IC50 of approximately 0 086 M against IGF-IR kinase In vitro research has demonstrated that treatment of ECC-1 and USPC-1 endometrial cancer cell lines with NVP-AEW541 leads to altered cell cycle progression induction of apoptosis and suppression of proliferation Furthermore NVP-AEW541 has been shown to enhance radiosensitivity specifically in PTEN wild-type cancer cell lines indicating its potential utility as an adjunctive therapeutic agent in oncology research
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