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Medchemexpress LLC NVP-BSK805 | 1092499-93-8 | 490.55 | 100 MG
Supplier: Medchemexpress LLC HY14722100MG
NVP-BSK805 is an ATP-competitive inhibitor of JAK2, showing high potency with an IC50 of 0.48 nM for JAK2 JH1. It also inhibits full-length wild-type JAK2 and FL JAK2 V617F activity, demonstrating IC50s of 0.58 ± 0.03 nM and 0.56 ± 0.04 nM respectively. This compound is known to suppress the growth of JAK2V617F-bearing acute myeloid leukemia cell lines.
- ATP-competitive JAK2 inhibitor
- Inhibits full-length wild-type JAK2
- Suppresses growth of JAK2V617F-bearing acute myeloid leukemia cell lines
- Blocks STAT5 phosphorylation
- Bias for JAK2 over JAK1 and JAK3 inhibition in JAK2V617F-mutant cell lines
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