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Apexbio Technology LLC NVP-BSK805 1092499-93-8 10mg
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Supplier:  Apexbio Technology LLC A367510

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NVP-BSK805 (CAS 1092499-93-8) is a selective Janus kinase 2 (JAK2) inhibitor It acts by blocking JAK2-mediated phosphorylation and subsequent activation of signal transducer and activator of transcription (STAT) proteins particularly STAT5 In kinase assays NVP-BSK805 potently inhibits wild-type JAK2 and the JAK2V617F mutant with IC50 values of approximately 0 58 nM and 0 56 nM respectively It suppresses STAT5 phosphorylation in JAK2-driven cell lines (CHRF-288-11 SET-2 and HEL) and inhibits STAT5 activation in animal models expressing JAK2V617F or treated with erythropoietin highlighting its utility in research on JAK2-related signaling and disorders

Catalog No. 50-000-63200


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