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Medchemexpress LLC Nvp-bsk805 dihydrochloride | 1942919-79-0 | 99.4% | 563.47 | 1 ML
Supplier: Medchemexpress LLC HY14722A10MM/1ML
NVP-BSK805 dihydrochloride is a potent, ATP-competitive JAK2 inhibitor. It targets JAK2 JH1, wild-type JAK2, and FL JAK2 V617F activity, effectively suppressing the growth of JAK2V617F-bearing acute myeloid leukemia cell lines and blocking STAT5 phosphorylation. It also enhances the efficacy of vincristine treatment in drug-resistant cancer cells.
- ATP-competitive inhibitor.
- Highly potent and selective JAK2 inhibitor.
- Inhibits full-length wild-type JAK2 and FL JAK2 V617F activity.
- Suppresses the growth of JAK2V617F-bearing acute myeloid leukemia cell lines.
- Blocks STAT5 phosphorylation.
- Shows bias for JAK2 over JAK1 and JAK3 inhibition.
- Improves P-gp inhibitory activity.
- Increases sensitization of drug-resistant cancer cells to vincristine treatment.
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