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Apexbio Technology LLC O4I1 175135-47-4 200mg
Supplier: Apexbio Technology LLC B6047200
O4I1 (CAS 175135-47-4) is a potent small molecule inducer of Oct3/4 (also known as POU5F1 or Oct4) a transcription factor essential for embryonic stem cell self-renewal and pluripotency O4I1 enhances Oct3/4 expression and stability significantly increasing transcriptional activity in multiple human somatic cell types Treatment of HEK293 cells with O4I1 at 10 M and 20 M for 72 hours resulted in approximately 2 5-fold and 4-fold elevations in Oct3/4 mRNA levels respectively Increased gene and protein expression of Oct3/4 was also observed in human primary and neonatal fibroblast cultures These properties make O4I1 a valuable tool for studying cellular reprogramming and stem cell biology
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