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Medchemexpress LLC OGG1-IN-08 | 350997-39-6 | 99.18% | 261.13 | 1 ML
Supplier: Medchemexpress LLC HY11290210MM/1ML
OGG1-IN-08 is a potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor with an IC50 value of 0.22 μM. It decreases both the glycosylase and lyase activities of OGG1. The product is for research use only and not sold to patients.
- Potent 8-oxoguanine DNA glycosylase-1 (OGG1) inhibitor
- IC50 value of 0.22 μM against OGG1
- Decreases both the glycosylase and lyase activities of OGG1
- Inhibits different DNA glycosylases activities: NEIL1 (84.56%), NTH1 (63.09%), and Fpg (91.74%) at 50 μM
- Inhibitory OGG1 lyase activity on a substrate containing an AP site at 10 μM
- Decreases the number of bases released by OGG1 for both 8-oxo-Gua and FapyGua at 10 μM
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