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Apexbio Technology LLC Olcegepant(Synonyms: BIBN4096BS, BIBN 4096 BS, BIIBN4096BS, BIIBN-4096BS, Olcegepant hydrochloride), 5mg, CAS: 204697-65-4.
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Supplier:  Apexbio Technology LLC A36805

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Olcegepant (CAS 204697-65-4) is a non-peptide antagonist targeting the calcitonin gene-related peptide type 1 (CGRP1) receptor which mediates neurogenic inflammatory pain pathways implicated in migraine pathophysiology In functional assays using SK-N-MC cells olcegepant blocks CGRP-induced cAMP generation (pA2 11 2) and demonstrates potent receptor inhibition (IC50 0 1 nM in human cerebral arteries) Animal studies indicate olcegepant reduces capsaicin-induced Fos expression in the spinal trigeminal nucleus suggesting it acts centrally rather than peripherally Clinical trials indicate olcegepant ameliorates migraine severity without vasoconstrictive effects highlighting its relevance as a research tool for migraine therapeutics

Catalog No. 50-224-0171


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