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Apexbio Technology LLC Olcegepant,5mg CAS# 204697-65-4
SDP

Supplier:  Apexbio Technology LLC A36805

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Olcegepant Description:IC50: 0.1nM on human brain vessels [1] Olcegepant is the first potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor, a key modulator in neurogenic inflammatory pain. Under development by Boehringer Ingelheim GmbH, olcegepant is an intravenously formulated treatment for acute attacks of migraine. In vitro: Functional studies with SK-N-MC cells demonstrated that CGRP-induced cAMP production was antagonised by both CGRP- (8-37) and olcegepant with pA2 values of 7.8 and 11.2, respectively. [1]. Other sizes are also available. Please inqury us for quote.

Catalog No. 50-224-0171


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