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Medchemexpress LLC Olcegepant (BIBN-4096) | 204697-65-4 | 99.6% | 869.65 | 5 MG
Supplier: Medchemexpress LLC 5MGHY10095
Olcegepant (BIBN-4096) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor. It exhibits high affinity for the human CGRP receptor and can reverse CGRP-mediated vasodilation. Olcegepant has been studied for its role in inhibiting neurogenic vasodilation and reducing mechanical allodynia in animal models of migraine.
- Potent and selective non-peptide CGRP1 receptor antagonist
- IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP
- Exhibits higher affinity for human CGRP receptor than endogenous ligand CGRP
- Reverses CGRP-mediated vasodilation in human cerebral vessels
- Inhibits neurogenic vasodilation in animal models of migraine pathophysiology
- Reduces mechanical allodynia in CCI-ION rats
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