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Cayman Chemical OmapatrIlat 10mg
Supplier: Cayman Chemical 3173810 MG
An orally bioavailable ACE and NEP inhibitor (IC50s = 1.7 and 5.3 nM, respectively, for the human enzymes); inhibits the angiotensin I-induced pressor response in normotensive rats (ED50 = 0.07 µmol/kg); lowers MAP in sodium-depleted spontaneously hypertensive rats at 30 µmol/kg; lowers MAP in rats when co-administered with bradykinin; increases tracheal plasma extravasation in a rat model of upper airway angioedema in a dose-dependent manner
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