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Medchemexpress LLC Oncrasin-1 | 75629-57-1 | 98.16% | 269.73 | 1 ML
Supplier: Medchemexpress LLC HY1666210MM/1ML
Oncrasin-1 is an RNA polymerase inhibitor that suppresses the phosphorylation of the largest subunit of RNA polymerase II and the expression of intronless reporter genes in sensitive cells. It effectively kills various human lung cancer cells with K-Ras mutations, leading to coaggregation of PKCι and splicing factors into megaspliceosomes and inducing malfunction in the RNA processing machinery. Oncrasin-1 is an anti-cancer agent and can be studied in research for lung cancer.
- RNA polymerase inhibitor
- Suppresses phosphorylation of the largest subunit of RNA polymerase II
- Suppresses expression of intronless reporter genes in sensitive cells
- Effectively kills various human lung cancer cells with K-Ras mutations
- Leads to coaggregation of PKCι and splicing factors into megaspliceosomes
- Induces malfunction in the RNA processing machinery
- Anti-cancer agent for lung cancer research
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