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Medchemexpress LLC Oncrasin-72 (NSC-743380) | 92407-90-4 | 97.6% | 50 MG
Supplier: Medchemexpress LLC HY13020750MG
Oncrasin-72 (NSC-743380) is an RNA polymerase II inhibitor that demonstrates activity in inhibiting growth and inducing cell death in human cancer cells. It also exhibits antitumor activity through JNK activation and STAT3 inhibition. An analytical method for quantifying its concentration in biological fluids for pharmacokinetic studies has been developed and validated.
- Acts as an RNA polymerase II inhibitor
- Inhibits growth of human cancer cells
- Induces cell death in human cancer cells
- Exhibits antitumor activity via JNK activation
- Exhibits antitumor activity via STAT3 inhibition
- Quantifiable in biological fluids for pharmacokinetic studies
- Successfully quantified in rat plasma for different dose groups
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