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Apexbio Technology LLC ONO-7300243 638132-34-0 25mg
Supplier: Apexbio Technology LLC B781825
ONO-7300243 (CAS 638132-34-0) is a small-molecule antagonist of lysophosphatidic acid receptor 1 (LPA1) exhibiting an in vitro IC50 of 160 nM LPA1 mediates responses to lysophosphatidic acid (LPA) a bioactive phospholipid involved in cellular proliferation calcium signaling cell survival and motility as well as physiological processes such as smooth muscle contraction and immune regulation In animal studies oral administration of ONO-7300243 significantly reduced urethral pressure without affecting systemic blood pressure indicating utility in benign prostatic hyperplasia (BPH) research Currently ONO-7300243 remains at the preclinical research stage
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