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Medchemexpress LLC Ontunisertib | 2647949-48-0 | 99.95% | 469.49 | 50 MG
Supplier: Medchemexpress LLC HY16899050MG
Ontunisertib (AGMB-129) is an orally active and selective inhibitor of ALK5 (TGFβR1) that is restricted to the gastrointestinal tract. It functions by blocking the signaling of the pro-fibrotic TGFβ pathway. This compound is being investigated for its potential use in the research of fibrostenotic Crohn's disease. It is designed to act locally in the gastrointestinal tract, providing high exposure to the target tissue, and is then rapidly inactivated in the liver after absorption to mitigate potential systemic toxicities associated with TGFβ signaling inhibition.
- Orally active and selective ALK5 (TGFβR1) inhibitor.
- Gastrointestinal-restricted action.
- Blocks pro-fibrotic TGFβ pathway signaling.
- Potential for research in fibrostenotic Crohn's disease.
- Designed for local action in the GI tract with rapid inactivation in the liver to avoid systemic toxicity.
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