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Apexbio Technology LLC ONX-0914 (PR-957) 960374-59-8 100mg
SDP

Supplier:  Apexbio Technology LLC A4011100

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ONX-0914 (PR-957) is a selective inhibitor targeting the immunoproteasome subunit 5i (LMP7) a proteolytic component involved in antigenic peptide processing for MHC class I presentation By reversibly binding the 5i-specific catalytic pocket ONX-0914 impairs the production of pro-inflammatory cytokines in activated human peripheral blood mononuclear cells (PBMCs) and suppresses IL-17 secretion during Th17 cell differentiation ONX-0914 has been employed experimentally in preclinical models of autoimmune conditions such as arthritis colitis and diabetes Reported IC50 values are approximately 5 15 nM for the 5i subunit demonstrating selective preference over constitutive proteasome subunits

Catalog No. 50-000-64380


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