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Apexbio Technology LLC Orexin A (human, rat, mouse)(Synonyms: Hypocretin-1, Hcrt-1, Orexin-A, Orexin 1, Hypocretin 1 (human, rat, mouse), OXA), 1mg, CAS: 205640-90-0.
Supplier: Apexbio Technology LLC B51171
Orexin A (human rat mouse CAS 205640-90-0) is a hypothalamic neuropeptide composed of 33 amino acids functioning as an endogenous agonist at orexin-1 and orexin-2 receptors Binding to these G-protein coupled receptors orexin A regulates multiple physiological processes including appetite arousal states locomotion hypothalamic-pituitary-adrenal axis activity and pain perception thresholds Preclinical studies have demonstrated that intravenous administration of orexin A (3 30 mg/kg) significantly increases paw withdrawal latency in thermal nociception assays suggestive of analgesic potential Hence orexin A serves as a useful tool for investigating neuroendocrine control mechanisms and corresponding therapeutic targets
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