Medchemexpress LLC Osimertinib dimesylate | 2070014-82-1 | 99.2% | C30H41N7O8S2 | 100 MG

Supplier:  Medchemexpress LLC HY79077100MG

Osimertinib dimesylate is an irreversible and mutant selective EGFR inhibitor, effective against EGFRL858R and EGFRL858R/T790M with IC50s of 12 and 1 nM respectively. It demonstrates similar potency to early generation tyrosine kinase inhibitors (TKIs) in inhibiting EGFR phosphorylation in EGFR cells and potently inhibits phosphorylation in T790M mutant cell lines. This compound offers improved rat PK, reduced hERG affinity, and enhanced IGF1R margins. Its profile provides broader chemical diversity, showing comparable efficacy at low doses.

• Irreversible and mutant selective EGFR inhibitor
• Potently inhibits EGFR phosphorylation in T790M mutant cell lines
• Improved rat PK and reduced hERG affinity
• Broader chemical and profile diversity
• Comparable efficacy at low doses

Catalog No. 50-004-34419