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Apexbio Technology LLC OSU-03012 (AR-12) 742112-33-0 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A28465.1
OSU-03012 (AR-12 CAS 742112-33-0) is a small molecule inhibitor targeting 3-phosphoinositide-dependent kinase-1 (PDK-1) with a reported IC50 of approximately 5 M OSU-03012 demonstrates increased potency compared to an earlier-generation compound OSU-02067 In cellular studies employing PC-3 prostate cancer cells OSU-03012 inhibits proliferation and induces apoptosis effects partially reversible through overexpression of constitutively active Akt or PDK-1 Additionally OSU-03012 reduces growth and suppresses phosphorylation of Akt at Thr308 in vestibular schwannoma (VS) cells and malignant schwannoma (HMS-97) cells with preferential activity over normal human Schwann cells Thus OSU-03012 serves as an investigative tool in cancer research exploring the PDK-1/Akt signaling pathway
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