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Cayman Chemical OxalIplatIn 50mg

Supplier: Cayman Chemical 1310650 MG
A DNA-crosslinking agent; induces the formation of DNA inter- and intrastrand crosslinks and DNA-protein crosslinks, inhibits DNA and RNA synthesis, and induces apoptosis in cancer cells; is cytotoxic to cisplatin-sensitive A2780(1A9) and KB-3-1 cells and cisplatin-resistant A2780-E(80) and KB-CP20 cells (IC50s = 0.12, 0.39, 4.7, and 2.7 µM, respectively); reduces tumor growth in an HCCLM3 mouse xenograft model at 5 or 10 mg/kg once per week
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