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Medchemexpress LLC Oxidopamine hydrochloride | 28094-15-7 | 99.9% | 50 MG
SDP

Supplier:  Medchemexpress LLC HYB108150MG

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Oxidopamine (6-OHDA) hydrochloride is an antagonist of the neurotransmitter dopamine. It is a widely used neurotoxin that selectively destroys dopaminergic neurons. It promotes COX-2 activation, leading to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion and can be used for the research of Parkinson's disease (PD), attention-deficit hyperactivity disorder (ADHD), and Lesch-Nyhan syndrome.

  • Selectively destroys dopaminergic neurons.
  • Promotes COX-2 activation.
  • Leads to PGE2 synthesis and pro-inflammatory cytokine IL-1β secretion.
  • Can be used for research of Parkinson's disease, attention-deficit hyperactivity disorder, and Lesch-Nyhan syndrome.
  • Decreases viability of Neuro-2a and SH-SY5Y cells in a concentration-dependent manner.
  • Induces apoptosis and mitochondrial membrane depolarization in PC12 cells.
  • Increases caspase-3, -8, and -9 activities.

Catalog No. 50-004-11773


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