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Cayman Chemical OxythIamInchlorIde hydroch 25g
Supplier: Cayman Chemical 2995325 G
A thiamine antimetabolite; converted by thiamine pyrophosphokinase to oxythiamine pyrophosphate; decreases transketolase activity in and is cytotoxic to MDA-MB-231 breast cancer cells at 5 mM; inhibits the nonoxidative synthesis of ribose and decreases RNA and DNA synthesis in MIA PaCa-2 pancreatic cancer cells at 0.5 µM; induces cell cycle arrest at the G0/G1 phase and apoptosis in an Ehrlich murine spontaneous adenocarcinoma model; reduces tumor growth in an SMMC mouse xenograft model in combination with sorafenib; has been used to induce thiamine deficiency in mice
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