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Medchemexpress LLC P 22077 | 1247819-59-5 | 98.4% | 315.32 | 50 MG
Supplier: Medchemexpress LLC HY1386550MG
P 22077 is a cell-permeable ubiquitin-specific protease 7 (USP7) inhibitor with an EC50 of 8.01 μM. It also inhibits USP47 with an EC50 of 8.74 μM.
- USP7 inhibitor (EC50: 8.01 μM)
- USP47 inhibitor (EC50: 8.74 μM)
- Cell-permeable
- Inhibits a smaller subset of DUBs at 15-45 μM
- Causes DUBs inhibition in HEK293T cells at 25 μM
- Greatly reduces cell viability of neuroblastoma (NB) cells
- Increases p53 activity and induces apoptosis in p53 wild-type and HDM2-expressing NB cells at 10 μM
- Enhances cytotoxic effect of Dox and VP-16 on NB cells, and enhances Dox- and VP-16-induced p53-mediated apoptosis at 5 μM
- Shows potent antitumor activities in xenograft mouse models bearing IMR-32-derived tumors
- Exhibits antitumor effects in mice bearing SH-SY5Y-derived tumors and NGP-derived tumors
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