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Cayman Chemical P4pal10trIfluoROCTAte sal 10mg
Supplier: Cayman Chemical 3691310 MG
A PAR4 and FPR2 antagonist and an FFAR2 agonist; selectively inhibits the aggregation of isolated human platelets induced by AYPGKF-NH2 (IC50 = 0.5-1 µM) over SFLLRN-NH2, U-46619, ristocetin, ADP, or collagen at 5 µM; inhibits WKYMVm- but not fMLF-induced increases in intracellular calcium in isolated human neutrophils; induces superoxide production in TNF-α primed Cmp58-stimulated isolated human neutrophils; reduces myocardial infarct size in a rat model of coronary artery ligation-induced ischemia-reperfusion injury at 1, 3, or 10 UG/kg; increases the paw withdrawal threshold in rat models of osteoarthritis induced by monoiodoacetate injection into the knee joint or medial meniscal transection
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