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Apexbio Technology LLC PA-824(Synonyms: Pretomanid, Nitroimidazooxazine, PA824, Pretomanide), 10mM (in 1mL DMSO), CAS: 187235-37-6.
Supplier: Apexbio Technology LLC A17365.1
PA-824 (CAS 187235-37-6) is a bicyclic nitroimidazole derivative exhibiting antimycobacterial activity against Mycobacterium tuberculosis Its bactericidal mechanism entails inhibition of ketomycolate biosynthesis and enzymatic nitro-reduction leading to intracellular release of nitric oxide killing both replicating and non-replicating M tuberculosis Reported MIC values range from 0 015 g/ml to 0 25 g/ml PA-824 demonstrates activity against drug-sensitive and drug-resistant tuberculosis strains supporting its utility in tuberculosis research and therapeutic investigations
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