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Bachem PACAP-38 (human, mouse, ovine, porcine, rat) Trifluoroacetate

Supplier:  Bachem 4031157.1000

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PACAP-38 (human, mouse, ovine, porcine, rat) Trifluoroacetate, H-His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2, 124123-15-5, C203H331N63O53S, Mr 4534.32, 1mg. Pituitary Adenylate Cyclase Activating Polypeptide-38 (human, mouse, ovine, porcine, rat), PACAP (1-38), human, ovine, rat. Kojro et al. observed that the PAC1 agonists PACAP-27 (H-1172) and PACAP-38 strongly increased the activity of a-secretase. Upregulation of this APP-degrading enzyme promotes the non-amyloidogenic processing of APP, i.e. reduces the production of Ab40/42, and thus may help to prevent Alzheimer’s disease. Nasally applied PACAP-38 in APP[V717I]-transgenic mice additionally enhanced the production of the Ab-degrading enzyme neprilysin via induction of somatostatin.

Catalog No. NC0089133


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