Manufacturer: Bachem 4031157.1000
PACAP-38 (human, mouse, ovine, porcine, rat). 1mg. Salt Form: Trifluoroacetate. 124123-15-5. Mol. Weight: 4534.32. Formula: C203H331N63O53S. Kojro et al. observed that the PAC1 agonists PACAP-27 (H-1172) and PACAP-38 strongly increased the activity of α-secretase. Upregulation of this APP-degrading enzyme promotes the non-amyloidogenic processing of APP, i.e. reduces the production of Aβ40/42, and thus may help to prevent Alzheimer’s disease. Nasally applied PACAP-38 in APP[V717I]-transgenic mice additionally enhanced the production of the Aβ-degrading enzyme neprilysin via induction of somatostatin.
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