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Medchemexpress LLC Padsevonil | 1294000-61-5 | 99.7% | 432.80 | 10 MG
Supplier: Medchemexpress LLC HY1090091MG
Padsevonil (UCB0942) is a potent antiepileptic agent that selectively acts on presynaptic and postsynaptic targets. It binds to synaptic vesicular protein 2 (SV2) with high affinity and is also a positive allosteric modulator and partial agonist of GABAAR, showing high potency against α1 and α5 receptors.
- Regulates GABAAR activity through allosteric sites on the receptor in CHO cells.
- Enhances natural GABAAR activity in primary rat neurons.
- Has protective effects on mouse models of acute epilepsy.
- Shows a protective effect in a rodent model of chronic epilepsy.
- Significantly decreased hippocampal paroxysmal discharges dose-dependently in kainate treated male mice.
- Produced dose-related suppression in the cumulative duration of spontaneous spike and wave discharges in platinum electrodes treated male Wistar rats.
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