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Cayman Chemical PalmItelaIdIc AcId-d13 500ug
SDP

Supplier:  Cayman Chemical 27713500 UG

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An inhibitor of MAGL (IC50s 14 and 27 nM for human and rat enzyme respectively) selective for MAGL over ABHD6 and PLA2G7 (IC50s 2 7 and 10 M respectively) as well as a panel of 33 serine hydrolases and a panel of 95 enzymes receptors transporters and ion channels at 10 M selective for MAGL over CYP1A2 CYP2C9 CYP2C19 and CYP3A4/5 (IC50s 50 M) inhibits MAGL activity in mouse and rat brain ex vivo (ED50s 1 4 and 0 5 mg/kg respectively) decreases brain levels of 2-AG in mice and rats reduces formalin-induced paw-licking time in rats

Catalog No. 50-294-0423


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