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Medchemexpress LLC Pamidronate disodium pentahydrate | 109552-15-0 | 98.0% | 1 ML
SDP

Supplier:  Medchemexpress LLC HYB073010MM/1ML

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Pamidronate disodium pentahydrate is a second-generation nitrogen-containing bisphosphonate supplied as a 10 mM solution. It inhibits bone loss by significantly inhibiting subchondral bone loss in early osteoarthritis, achieved by upregulating osteoprotegerin expression and inhibiting RANKL, MMP-9, and TLR-4 in cartilage. It also inhibits Wnt and β-catenin signaling and is applicable for research on osteoporosis and osteosarcoma.

  • Inhibits the cell viability of osteosarcoma cells (POS, HMPOS, COS31) at concentrations ranging from 0.001-1000 μM over 72 hours, without cytotoxicity to fibroblasts.
  • Improves bone structure and alleviates degenerative changes of cartilage.
  • Exhibits a protective effect against osteoarthritis in rabbit models.
  • Increases bone volume fraction (BV/TV), trabecular thickness (TbTh), and trabecular number (TbN).
  • Reduces cartilage surface erosion and increases chondrocyte and matrix content.

Catalog No. 50-004-08941


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