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Apexbio Technology LLC Panobinostat (LBH589) 404950-80-7 10mM (in 1mL DMSO)
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Supplier:  Apexbio Technology LLC A81785.1

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Panobinostat (LBH589) is a histone deacetylase (HDAC) inhibitor targeting class I II and IV HDAC enzymes regulating gene expression through histone hyperacetylation In vitro studies indicate panobinostat induces apoptosis and growth arrest in Ph-negative acute lymphoblastic leukemia (ALL) cell lines T-cell (MOLT-4) and pre-B cell (Reh) via caspase activation PARP cleavage and downregulation of c-Myc accompanied by H3K9 and H4K8 hyperacetylation and elevation of cell-cycle regulators (p21 p27) Panobinostat has shown anti-proliferative effects in various cancer models including cutaneous T-cell lymphoma and multiple myeloma (IC50 5-30 nM) and serves as a research tool in studies assessing epigenetic regulation and tumor biology

Catalog No. 50-000-62653


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