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Apexbio Technology LLC Paroxetine HCl 78246-49-8 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B22525.1
Paroxetine hydrochloride (CAS 78246-49-8) is a selective serotonin reuptake inhibitor (SSRI) that inhibits the presynaptic serotonin transporter (SERT) leading to increased synaptic serotonin levels (IC 14 M) and antidepressant effects Recent studies indicate that it also attenuates the phosphorylation activity of G protein-coupled receptor kinase 2 (GRK2) suggesting additional utility in the modulation of neuronal signaling pathways Paroxetine HCl is commonly used as a tool compound in mechanistic research on major depressive disorder obsessive-compulsive disorder and panic disorder as well as in the development and screening of CNS-active agents and GPCR signaling probes
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