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AdipoGen PARP-3 h Hishigh purity
SDP

Supplier:  AdipoGen AG40T0013C010

Encompass_Preferred

Protein. Human full-length PARP-3 ARTD3 is fused to a HA-tag and a His-tag. Source Sf21 cells. Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 50mM imidazole, 0.2% NP-40 and 10% glycerol. Purity >98% SDS-PAGE. PARP-3 is involved in the base excision repair BER pathway, by catalyzing the polyADP-ribosylation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.

Catalog No. 50-256-2797


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