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Medchemexpress LLC PD 407824 | 622864-54-4 | 99.0% | 328.32 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY189615MG

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PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. It is also a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4.

  • Inhibits Chk1 with an IC50 of 47 nM.
  • Inhibits WEE1 with an IC50 of 97 nM.
  • Blocks CHK1, leading to down-regulation of p21, activation of CDK8/9, and subsequent depletion of SMAD2/3.
  • Selective for Chk1 and WEE1 over PKC and Cdk4.

Catalog No. 50-003-85487


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