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Medchemexpress LLC PD 90780 | 77422-99-2 | 98.8% | 362.34 | 10 MM x 1 ML
Supplier: Medchemexpress LLC HY110166100MG
PD 90780 is a non-peptide antagonist of nerve growth factor (NGF). It interacts with NGF, preventing NGF from binding with p75NTR. PD 90780 inhibits NGF-p75NTR interaction with IC50s of 23.1 μM in PC12 cells and 1.8 μM in PC12nnr5 cells.
- Affects 125I-BDNF binding to truncated p75NTR at concentrations of 0.1-100 μM over 2 hours.
- Inhibits 125I-NGF cross-linking to p75NTR.
- Decreases TrkA phosphorylation resulting from NGF binding at a dose of 300 μM.
- Inhibits NGF-p75NTR interaction with IC50 values of 23.1 μM and 1.8 μM in PC12 cells and PC12nnr5 cells, respectively.
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