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Apexbio Technology LLC PD153035 hydrochloride 153436-54-5 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A81995.1
PD153035 hydrochloride (CAS 153436-54-5) is a small molecule inhibitor that targets the epidermal growth factor receptor (EGFR) tyrosine kinase by competitively binding to the ATP-binding site thereby suppressing EGFR kinase activity with an IC50 of 0 025 nM In various EGFR-overexpressing human tumor cell lines including A431 Difi DU145 MDA-MB-468 ME180 and C4i PD153035 inhibits EGF-dependent EGFR phosphorylation and subsequently reduces cell proliferation and colony formation with IC50 values ranging from 0 22 M to 2 5 M Additionally the compound partially inhibits the related HER2/neu receptor supporting its use in research exploring EGFR and HER2 signaling pathways and targeted cancer therapies
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