ABclonal Technology PE Rabbit anti-Human CD40 mAb

Supplier:  ABclonal Technology A26129200T

This gene is part of the TNF-receptor superfamily encoding a receptor on antigen-presenting cells that mediates immune and inflammatory responses including T cell-dependent immunoglobulin class switching memory B cell development and germinal center formation It is regulated by the AT-hook transcription factor AKNA which controls both the receptor and its ligand aiding in homotypic cell interactions The receptor interacts with TNFR2 to mediate signal transduction and is essential for amyloid-beta-induced microglial activation an early event in Alzheimer s disease Mutations in this gene cause autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3) Multiple splice variants encoding different isoforms have been identified

Catalog No. 50-000-12566