ABclonal Technology PE Rabbit anti-Mouse TNF-a mAb

Supplier:  ABclonal Technology A27472500T

This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily Members of this family are classified based on primary sequence function and structure This protein is synthesized as a type-II transmembrane protein and is reported to be cleaved into products that exert distinct biological functions It plays an important role in the innate immune response as well as regulating homeostasis but is also implicated in diseases of chronic inflammation In mouse deficiency of this gene is associated with defects in response to bacterial infection with defects in forming organized follicular dendritic cell networks and germinal centers and with a lack of primary B cell follicles Alternative splicing results in multiple transcript variants

Catalog No. 50-000-11733