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Apexbio Technology LLC Pemetrexed disodium hemipenta hydrate 357166-30-4 200mg
Supplier: Apexbio Technology LLC A3707200
Pemetrexed disodium hemipenta hydrate (CAS 357166-30-4) is a multitargeted antifolate that inhibits key enzymes in folate metabolism including thymidylate synthase (TS) dihydrofolate reductase (DHFR) and glycinamide ribonucleotide formyltransferase (GARFT) with Ki values for its pentaglutamate form of 1 3 nM 7 2 nM and 65 nM respectively Compared to the monoglutamate form the pentaglutamate exhibits enhanced inhibitory potency particularly against TS and GARFT Pemetrexed is approved for the treatment of advanced non-squamous non-small cell lung cancer In preclinical models it additionally modulates renal uptake of radiolabeled folates These features support its utilization in studies of folate pathway inhibition and cancer therapy
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