Medchemexpress LLC Peramivir | 330600-85-6 | 98.3% | 382.45 | 100 MG

Supplier:  Medchemexpress LLC HY17015100MG

Peramivir trihydrate is a highly potent, selective, and orally active inhibitor of influenza virus neuraminidase, showing IC50 values from 0.9 to 4.3 nM across nine NA subtypes.

• Highly potent, selective, and orally active influenza virus neuraminidase (NA) inhibitor.
• Shows IC50 values ranging from 0.9 to 4.3 nM for nine NA subtypes.
• Nontoxic to macrophages at concentrations up to 40 μM.
• Inhibits cytokine release in LPS-induced hPBMCs.
• Inhibits LPS-induced cytokine storm and attenuates acute lung injury in mice.
• Prolongs survival in cytokine storm syndrome model mice.
• Decreases various cytokines and chemokines, including TNF-a, IFN-a, and IL-6.
• Provides significant protective effects on lung tissues.
• Rescues BALB scid mice from lethal influenza B virus challenge in immunocompromised models.

Catalog No. 50-003-86053